Pyreneese berghond pups

We verwachten oktober 2025 een nestje. U kunt ons een bericht sturen als u geïnteresseerd bent om een pup te krijgen van deze combinatie. JADE-LITTER Liena de Alba de los Danzantes (Navarre de Bigorionnes x Riglos de Alba de los Danzantes) & Denny du domaine de Blanche-Neige (Diamant Suzette du domaine de Blanche-Neige x Pastore Romeo du Grand Tendre) Het Jade Litter Reinigend en beschermend: Jade staat bekend om zijn reinigende en beschermende werking, vooral tegen lichamelijk letsel. Harmonie en evenwicht: Het bevordert harmonie en evenwicht, en trekt voorspoed, geluk en welvaart aan. Emotionele ondersteuning: Jade helpt bij het loslaten van negatieve emoties en bevordert zelfverwezenlijking. Feng Shui: Het wordt vaak gebruikt in feng shui om gevoelens van harmonie te creëren en rijkdom aan te trekken.

Liena de Alba de los Danzantes

Gezondheidsresultaten

Official Health results Hip dysplasia (HD A),

Elbow dysplasia (ED) and Patellar luxation (Pl) FREE Osteochondritis Dissecans (OCD) ,

and Lumbosacral disease FREE …….ECVO TEST all Eye Diseases FREE … DNA TEST, behavior and fear test . All results are Sublime

Denny du domaine de Blanche-Neige

Gezondheidsresultaten

Pyrenäenberghund - Züchter

“A Pyrs Love story never ends…” du domaine de Blanche-Neige

Result certificate #233545 Detection of c.118G>A mutation in SOD1 gene causing degenerative myelopathy in dogs

Result: Mutation was not detected (N/N)

Customer: Lenka Filipová, Králová 11, 78391 Medlov, Czec h Rep ub lic Sample: Sample: 23-41662 Date rece ived: 20.06.2023 Sample type: buccal swab Information provided by the customer Name: Du Domaine Blanche-Neige Denny Breed: Pyrenean Mountain Dog (Great Pyrenees) Microchi p: 2 760945 0053 9838 Reg. number: CMKU/PHP/2107/-21/20/ 22 Date of birth: 27.07.2020 Sex: male The identity of the animal has been checked by Ing. Nikola Eretová, G enomia s.r.o.

G enomia s.r.o, Republikánská 6, 3120 0 Plzeň, C zech Republic www.genomia.c z, laborator@genomia.cz, tel: +420 373 749 999 Report verification code is: BHEF-54MW-W6BR-F5XJ-FN8Y. You can verify report online at ww w.genomia.cz Without a written consent by the lab, the report must not be reproduced unless as a whole. The result refers only to the sample as received. Genomia is not responsible for the accuracy of the information provided by the customer.

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Legend: N/N = wild-type genotype. N/P = carrier of the mutation. P/P = mutated genotype (individual will be most probably affected with the disease). (N = negative , P = positive) Explanation Presence or absence of c.118G>A mutation in SOD1 gene causing degenerative myelopathy in many canin e breeds was tested. This mutation is sometimes referred to as SOD1A. Affected dogs have progressi ve loss of movement and gradual worsening of the condi tion up to complete paralysis. The age of disease onset and symptoms severity vary among the breeds. Mutation SOD1A is inherited as an autosomal recessive trait. That means the disease affects dogs with P/P genotype only. The dogs wi th N/P genotype are considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genot ype distributi on can be expect ed: 25 % N/N (healthy non-carriers), 25 % P/P (affected), and 50 % N/P (healthy carriers). The test does not exclude existence of another, nowadays unknown, mut ation which can cause DM. I n Bernese Mountain Dogs, there has been identified also SOD1B mutation responsible for DM - this test does not refer about SOD1B. Analysis was performed by the partner laboratory. Genomi a guarantees t he quality of its partner's services. M ethod: SOPAgriseq_canin e, n gs Date of issue: 12.07.2023 Date of testing: 20.06.2023 - 12.07.2023 Approved by: Mgr. Martina Šafrov á, Laboratory Manager

Result certificate #233544 Detection of g.15295122-15295126del mutation in SACS gene causing neuronal degeneration in Great Pyrenees dogs

Result: Mutation was not detected (N/N)

Customer: Lenka Filipová, Králová 11, 78391 Medlov, Cz ec h Rep ub lic Sample: Sample: 23-41662 Date rece ived: 20.06.2023 Sample type: buccal swab Information provided by the customer Name: Du Domaine Blanche-Neige Denny Breed: Pyrenean Mountain Dog (Great Pyrenees) Microchi p: 2 760945 0053 9838 Reg. number: CMKU/PHP/2107/-21/20/22 Date of birth: 27.07.2020 Sex: male The identity of the animal has been checked by Ing. Nikola Eretová, Genomia s.r.o.

Genomia s.r.o, Republikánská 6, 3120 0 Plzeň, C zech Republic www.genomia.cz, laborator@genomia.c z, tel: +420 373 749 999 Report verification code is: TC7Q-37BT-54B6-BTQW-AYTM. You can verify report online at www.genomia.cz Without a written consent by the lab, the report must not be reproduced unless as a whole. The result refers only to the sample as received. Genomia is not responsible for the accuracy of the information provided by the customer.

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Legend: N/N = wild-type genotype. N/P = carrier of the mutation. P/P = mutated genotype (individual will be most probably affected with the disease). (N = negative , P = positive) Explanation Presence or absence of g.15295122-15295126del mutation in SACS gene causing neuronal degeneration in Great Pyrenees dogs was tested. The disease is ch aracterised by degeneration of the cent ral nervous system that leads to progressive cerebellar at axi a (movement coordination dis order) and spastici ty (condi tion with increased muscle tone). The clinical sympt oms appear very soon at the age of 4 months and someti mes even earlier. The disease gradually progresses during next several years and the symptoms get worse. The af fected dogs have abnormal gait - clumsy or unc oordinated movement wi th a wide-base stanc e, slipping and sliding manoeuvring. Mutation that causes neuronal degeneration is inheri ted autos omally recessively whic h means that the disease develops only in those dogs who inherit mutated allele from both parents; di sease affects dogs wit h P/P genotype only. The dogs with N/P genotype are considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype distribution can be expected: 25 % N/N, 25 % P/P and 50 % N/P. M ethod: SOPAgriseq_canin e, n gs Date of issue: 12.07.2023 Date of testing: 20.06.2023 - 12.07.2023 Approved by: Mgr. Martina Šafrov á, Laboratory Manager

Result certificate #233543 Detection of c.1360_1373dup mutation in ITGA2B gene causing thrombasthenia in G reat Pyrenees

Result: Mutation was not detected (N/N)

Customer: Lenka Filipová, Králová 11, 78391 Medlov, Cz ec h Rep ub lic Sample: Sample: 23-41662 Date rece ived: 20.06.2023 Sample type: buccal swab Information provided by the customer Name: Du Domaine Blanche-Neige Denny Breed: Pyrenean Mountain Dog (Great Pyrenees) Microchi p: 2 76 0945 0053 9838 Reg. number: CMKU/PHP/2107/-21/20/ 22 Date of birth: 27.07.2020 Sex: male The identity of the animal has been checked by Ing. Nikola Eretová, Genomia s.r.o.

Genomia s.r.o, Republikánská 6, 3120 0 Plzeň, C zech Republic www.genomia.c z, laborator@genomia.cz, tel: +420 373 749 999 Report verification code is: WMAF-MK8X-RB9K-3QER-QEA1. You can verify report online at www.genomia.cz Without a written consent by the lab, the report must not be reproduced unless as a whole. The result refers only to the sample as received. Genomia is not responsible for the accuracy of the information provided by the customer.

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Legend: N/N = wild-type genotype. N/P = carrier of the mutation. P/P = mutated genotype (individual will be most probably affected with the disease). (N = negative , P = positive) Explanation Presence or absence of c.1360_1373dup mutation in ITGA2B gene causing thrombastheni a in Great Pyrenees was tested. Glanzmann thrombasthen ia is a blood clott ing disorder in which platelet funct ion is i mpaired. Typical signs are small dots of blood on the skin an d mucous membranes (petechiae) and increased bleedi ng during injuries or surgery. Other signs may include frequent nose bleeds or the presence of blood in the st ool. Mutation that causes thrombasthenia is in herited autosomally recessively whic h means that the disease develops only in t hose dogs wh o i nherit mutated allele from both parents; disease affects dogs with P/P genotype only. The dogs wi th N/P genotype are considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype distribution can be expected: 25 % N/N, 25 % P/P and 50 % N/P. M ethod: SOPAgrise q_canin e, n gs Date of issue: 12.07.2023 Date of testing: 20.06.2023 - 12.07.2023 Approved by: Mgr. Martina Šafrová, Laboratory Manager

Result certificate #233546 Detection of c.73C>T mutation in VMD2 gene causing CMR1 disease in dogs

Result: Mutation was not detected (N/N)

Customer: Lenka Filipová, Králová 11, 78391 Medlov, Czec h Rep ub lic Sample: Sample: 23-41662 Date rece ived: 20.06.2023 Sample type: buccal swab Information provided by the customer Name: Du Domaine Blanche-Neige Denny Breed: Pyrenean Mountain Dog (Great Pyrenees) Microchi p: 2 760945 0053 9838 Reg. number: CMKU/PHP/2107/-21/20/ 22 Date of birth: 27.07.2020 Sex: male The identity of the animal has been checked by Ing. Nikola Eretová, Genomia s.r.o.

Genomia s.r.o, Republikánská 6, 3120 0 Plzeň, C zech Republic www.genomia.c z, laborator@genomia.cz, te l: +420 373 749 999 Report verification code is: M7WK-W577-M16A-48JK-425Q. You can verify report online at ww w.genomia.cz Without a written consent by the lab, the report must not be reproduced unless as a whole. The result refers only to the sample as received. Genomia is not responsible for the accuracy of the information provided by the customer.

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Legend: N/N = wild-type genotype. N/P = carrier of the mutation. P/P = mutated genotype (individual will be most probably affected with the disease). (N = negative , P = positive) Explanation Presence or absence of mutation c.73C>T in VMD2 gene causi ng CMR1 disease (Canine Multifocal Retinopathy type 1) in Great Pyrenees, English Mastiffs, Bullmastiff s, Aus tralian Shepherd and related breeds was tested. The mutation forms premature stopkodon (R25X) in canine VMD2 gene; the gene is responsible for right forming of pigment epithelium in retina. Clinically, rose-grey colored lesions are remarkable in retina. CMR disease usually arises before 4th month of age in an affected puppy. Total blindness usually comes in higher age. Mutation c.73C>T in VMD2 gene is inherited as an autosomal recessive trait. That means the disease affects dogs with P/P genotype on ly. Th e dogs with N/P genotype are considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype di stribution can be expected: 25 % N/N, 25 % P/P and 50 % N/P. M ethod: SOPAgriseq_canin e, n gs Date of issue: 12.07.2023 Date of testing: 20.06.2023 - 12.07.2023 Approved by: Mgr. Martina Šafrov á, Laboratory Manager

Denny du domaine de Blanche-Neige

Pedigree